Summary - Nothapodytes nimmoniana (Grah.) Mabb. is an endangered medicinal tree from Western Ghats of India. It yields Camptothecin (CPT), an anti-cancer alkaloid and is the most convenient source for large-scale production of CPT.Because of destructive harvesting, habitat loss, the population of this species has declined 50-80%. In view of the mounting demand and perceived threat to the native populations, the project addresses various issues of domestication of the said species.